Endocrine Abstracts

Since 2006 at our hospital, lifestyle modification, such as diet and exercise, for obese patients has been provided through a team approach with a physician, dietician, physical therapist and psychologist. From 2016, a surgeon, anesthesiologist and nurse were added to the team for metabolic/bariatric surgery. The aims of this study are to clarify the effectiveness and problems of lifestyle modification, and to clarify the characteristics of patients who transferred for surgica...

Motilin (M), erythromycin (EM) and ghrelin (G) are recognized as important regulators of gastrointestinal motor function in humans that are mediated by class I guanine nucleotide-binding protein (G protein)-coupled motilin receptor (MR) and growth hormone secretagogue receptor (GHSR). These receptors have also been demonstrated as clinically useful pharmacological targets. However, a molecular relationship between MR and GHSR activation has been unclear. We generated human MR ...

The motilin receptor (MLNR) belongs to a family of Class I G protein-coupled receptors, and is an important endogenous regulator of gastrointestinal motor function. Motilin and erythromycin (EM), two chemically distinct full agonists of the motilin receptor, bind to distinct regions of this receptor, while the action of these different chemical classes of agonists likely yields a common activation state of the cytosolic face of this receptor that is responsible for interaction...

Since 2006 at our hospital, lifestyle modification, such as diet and exercise, for obese patients has been provided through a team approach with a physician, dietician, nurse, physical therapist and psychologist. From 2016, a surgeon and anesthesiologist were added to the team for metabolic/bariatric surgery. The aims of this study are to clarify the effectiveness and problems of lifestyle modification for short-term intensive management (for 3 months) and long-term management...